Recidoro AM, Roof AC, Schmitt M, Worton LE, Petrie T, Strand N, Ausk BJ, Srinivasan S, Moon RT, Gardiner EM, Kaminsky W, Bain SD, Allan CH, Gross TS, Kwon RY.
J Bone Miner Res. 2014 May 7. doi: 10.1002/jbmr.2274. [Epub ahead of print]
In a recent article in the Journal of Bone and Mineral Research, researchers from the Orthopaedics Research Lab developed a model of Botulinum toxin (BTx)-induced muscle paralysis in adult zebrafish and examined its effects on intramembranous ossification during tail fin regeneration.
Intramuscular administration of BTx has been associated with impaired osteogenesis in diverse conditions of bone formation (e.g., development, growth, and healing), yet the mechanisms of neuromuscular-bone crosstalk underlying these deficits have yet to be identified. Motivated by the emerging utility of zebrafish (Danio rerio) as a rapid, genetically tractable, and optically transparent model for human pathologies (as well as the potential to interrogate neuromuscular-mediated bone disorders in a simple model... Read more...