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An interview with Seth S. Leopold, M.D.

Seth S. Leopold, M.D. Dr. Leopold ranked as a "Top Doctor" in the category of "Joint Replacement Surgery" according to Seattle Magazine (September 2007), specializes in knee and hip replacement surgery. He has a particular interest in the use of minimally-invasive joint replacement techniques to decrease post-operative pain, shorten the hospital stay, and help his patients recover more quickly following the surgery. He performs and teaches quadriceps-sparing total knee replacement, a new technique that may help patients return to function within weeks of knee replacement surgery, rather than months. His practice focuses on the care of patients with hip and knee arthritis, as well as those suffering with painful or failed joint replacements. 

Dr. Leopold received his medical degree with honors in research from Cornell University Medical College in New York. He completed his Orthopaedic training at the University of Chicago and performed a fellowship in Joint Replacement at Rush-Presbyterian-St. Luke’s Medical Center. Following this, he spent time teaching arthritis surgery and performing arthritis research while on a 3-year active-duty tour in the US Army Medical Corps, where he received two consecutive Outstanding Faculty Awards for his efforts. He has been recognized at the national level for his research into problems related to hip and knee arthritis. After leaving the military, Dr. Leopold joined the faculty of the UW Department of Orthopaedics and Sports Medicine as an associate professor in August 2002.

He sees patients at the Bone and Joint Center and at the Eastside Specialty Center.

Recently, Dr. Seth Leopold ranked as a "Top Doctor" in the category of "Joint Replacement Surgery" (News source:  Seattle Magazine, September 2007).

What do you most enjoy about your work?

Working in academic medicine allows me to spend time in three distinct, but related, areas: taking care of patients, doing research, and teaching orthopaedic surgery. I joined the UW faculty because the environment is supportive enough to allow me to continue to develop in all three areas.

In the area of patient care, I especially enjoy the close relationships I develop with patients whom I am able to follow over long periods of time. Most of those patients never even have surgery, but because of the nature of arthritic conditions, I see them from time to time to help them along with non-operative treatments. All throughout, they share family stories, outside interests, a bit about their history; sometimes I do the same. In the process, friendships form. When patients do come to surgery, I find it particularly gratifying that so many patients are able to do so well--both in terms of pain and function--following joint replacement.

What is your treatment philosophy?

I've heard the job of surgeon described as "part mentor, part coach, and part cheerleader." That’s not a bad summary of how I see myself in working with patients who have arthritis. Since most of the surgery I do is considered elective--usually life-improving, but seldom life-saving--the decision to have surgery can become very complicated. In other words, patients who decide to have arthritis surgery take a risk with their health (the operation itself), in the hope of obtaining a better quality of life. Because only the person with the pain knows when the time is right to make this choice, I would never tell an arthritis sufferer that he or she "needs" a joint replacement.

Rather, I prefer to help educate patients as to the risks and benefits of arthritis surgery, and am able to do this only after considering each patient's specific health problems, pain patterns, and desired life activities. Because of the very personal nature of this decision, there is no "cookbook" approach, and while my role in this process is important, I am fundamentally there in support of each individual patient. Once a patient decides to have surgery–-and after the surgery has taken place--my job as coach and cheerleader begins. How much of each depends on the needs of each individual patient.

What are your interests outside of medicine?

Since I'm the father of two young daughters, much of my free time is family time. We’ve moved to Seattle to enjoy the outdoors. My wife and I are avid backcountry campers and sea kayakers. I also enjoy telemark skiing and rock climbing. When not outdoors, I love to read. Authors I’ve been enjoying lately include James Salter (Light Years, Cassada), Paul Auster (Leviathan, The Music of Change, The New York Trilogy), and Stephen Ambrose (The Wild Blue).

What is the focus of your teaching efforts?

Apart from patient care, working with orthopaedic residents is the highlight of my job. I've developed a curriculum to help surgeons-in-training learn to read the scientific literature more critically--a topic that is really not formally taught in most medical schools. This has been pretty well received, and from my standpoint, is also great fun to do.

On the national level, I'm involved with orthopaedic education as one of the surgeons who helps decide which papers get presented at the annual meeting of the American Academy of Orthopaedic Surgeons in the area of adult hip reconstruction. I also was a co-developer of an educational CD-ROM for orthopaedic surgeons called "The Arthritic Knee," which was produced by the AAOS, and I currently work as a consultant reviewer for The Journal of Bone and Joint Surgery in the area of adult hip and knee surgery.

What do your most recent research efforts focus on?

For the most part, I do clinical research on treatments for hip and knee arthritis. I recently completed a prospective, randomized trial comparing a new injectable medicine for knee arthritis (a hyaluronic acid product called Synvisc) with an old standby--cortisone shots. I also completed a study looking at the one element of the physiological stress response to surgery--sometimes called the "fight or flight" response--in patients having major and minor knee operations. A relatively new interest of mine is investigating how certain non-scientific factors sometimes are associated with outcomes in orthopaedic research.

What is the focus of your clinical efforts?

I specialize in hip and knee replacement surgery. This includes taking care of patients with all types of arthritis when it affects those joints, as well as caring for adult patients with other acquired or developmental hip and knee problems, such as osteonecrosis (avascular necrosis), developmental/congenital hip dysplasia or dislocations, and post-traumatic problems of the hips or knees. Also, I can help patients who have had hip or knee replacements but who develop problems with those joints, such as severe persistent pain, dislocation, instability, infection, or loosening of the implants.

I am especially interested in some of the newer, less-invasive approaches to hip and knee replacement, including unicompartmental ("mini") knee replacement, minimally-invasive quadriceps-sparing total knee replacement, and less-invasive techniques of hip replacement surgery.

Selected bibliography of Dr. Leopold’s recent scientific publications:
  1. Leopold, S.S.; Warme, W.J.; Braunlich, E.F.; Shott, S.: Publication bias in the orthopaedic literature – "Risk factors" for a positive outcome. Presented at the 69th Annual Meeting of the American American Academy of Orthopaedic Surgeons (Dallas, TX), February 13-17, 2002.
  2. Leopold, S.S.; Warme, W.J.; Pettis, P.D.; Shott, S.: Increased frequency of acute local reaction to intra-articular hylan G-F 20 (Synvisc) in patients receiving more than one course of treatment. J Bone Joint Surg 84-A:1619-1623, 2002. (Read abstract here.)
  3. Leopold, S.S.; Battista, V.; Oliverio, J.A.: Safety and efficacy of intra-articular hip injection using anatomic landmarks. Clin Orthop 191: 192-197, 2001
  4. Leopold, S.S.; McStay, C.; Klafeta, K.; Jacobs, J.J.; Berger, R.A.; Rosenberg, A.G.: Primary repair of intraoperative disruption of the medial collateral ligament during total knee arthroplasty. J Bone Joint Surg 83-A: 86-91, 2001.
Latest patient-related articles by Dr. Leopold

Streaming video featuring Dr. Leopold

Video StillMinimally-Invasive Joint Replacement

Dr. Seth Leopold discusses less-invasive knee and hip replacement surgery in this UWTV video.




Minimally Invasive Total Knee Replacement Surgery

A 30-minute "patient's-eye view" televised feature of what it's like to go through minimally-invasive total knee replacement surgery.







Dr. Leopold's Contact Information:
  • Clinics: Bone and Joint Center: (206) 598-0685 or web site) or Eastside Specialty Center: (425) 646-7777 or web site
  • Patient Care Coordinator: Cindy Taber: (206) 598-3354

Last Updated: 9/25/2007


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