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Soft Tissue Masses: Diagnosis and Surgery for Benign and Cancerous Tumors (Sarcoma)

Last updated Friday, January 18, 2008

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Incidence and risk factors

Who gets masses and why?

Some 10,000 new soft tissue and bone sarcomas (cancerous growths) are diagnosed annually in the United States. Benign soft tissue tumors are discovered at a significantly higher rate than sarcomas.

Soft tissue tumors affect every segment of the population. However, sarcomas occur more often in children and young adults, and men have a slightly higher rate of sarcoma than women.

Some sarcomas are more prevalent among specific populations. For example, synovial sarcoma is more often found in young adults.

In the vast majority of cases, a soft tissue tumor is a spontaneous occurrence without a well-defined cause.

How is masses acquired (contagion, genetics, injury, lifestyle, etc)?

Evidence suggests that some genetic disorders and mutations predispose people to benign and cancerous soft tissue tumors. Exposure to radiation and environmental carcinogens has been associated with soft tissue tumors. Kaposi’s sarcoma is an example of an infection-induced soft tissue tumor –resulting from a type of herpes in patients who also have HIV.

Most people with a soft tissue tumor do not have a well-defined cause for their tumor. Lifestyle factors, injury, and infection have not been consistently proven to cause soft tissue tumors in the majority of cases.  

What is the role of genetics in acquiring or developing masses?

Rare genetic abnormalities and disorders can predispose people to benign and malignant soft tissue tumors. For example, a gene linked to neurofibromatosis – nerve-sheath tumors – has shown likelihood to become cancerous.

Is masses contagious?

Soft tissue tumors are not contagious.

Is probability for acquiring masses affected by diet, metabolism, lifestyle, etc?

Lifestyle and diet are not thought to play a role in the emergence of soft tissue tumors – benign or cancerous.

Is masses likely to result from injury or trauma?

Historically there have been many case associations between trauma and soft tissue masses, but data does not support trauma as the cause of such masses. More likely is that the trauma drew medical attention to the existing tissue mass.

One exception would be a ganglion cyst, a common, benign fluid-filled soft tissue mass that can be caused by injury. A ganglion cyst might develop after a knee injury, for instance. Such cysts usually move about more freely and are much softer than a sarcoma (cancerous growth).

Can masses be prevented?

Soft tissue tumors cannot be prevented, per se, but any discovered mass of unknown etiology that is growing should be evaluated by a specialist. Any sprain or hematoma that lasts longer than six weeks merits additional medical scrutiny.

Surgery for masses at the University of Washington

If you are interested in making an appointment to discuss this procedure, you can request an appointment using our online referrals website. To request a referral online, please click here. You can also call 206-598-4288 (outside the Seattle area: 800-440-3280) to make an appointment.


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