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Lupus Erythematosus.

Last updated Thursday, December 23, 2004

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Symptoms

What are symptoms of lupus erythematosus?

There is no uniform pattern of symptoms at the onset of lupus.

Fever, weakness, fatigue, or weight loss may be among the first signs of illness. A skin rash may appear on the face, neck, or arms. When this rash involves the nose and cheeks, it is called a butterfly rash. In people who are very sensitive to ultraviolet light, the rash may appear or get worse after exposure to the sun. Sometimes the fingers are unusually sensitive to cold and will turn blue on exposure. This color change is called Raynaud's phenomenon.

Another early sign of lupus may be joint pain in the hands, wrists, elbows, knees or ankles. Although the joints may become red, warm or swollen, the development of deformities is very uncommon. A feeling of stiffness in the joints and muscles upon awakening in the morning may accompany the joint pains, or may even occur without joint pain. Other common symptoms of the illness include muscle aches, swollen glands, lack of appetite, low grade temperature, hair loss, and nausea and vomiting.

There may be an increased tendency to get infections or to bleed easily. You may develop anemia. This is a condition in which one type of blood cell may be decreased in number, causing weakness and paleness, or even shortness of breath. Some people with lupus may have an increased tendency to form blood clots.

Other frequent symptoms include inflammation of the lining of some body parts (for example, the heart and lungs) causing symptoms of pain on breathing or shortness of breath. Kidney problems commonly occur. In the early stages, there may be no symptoms of kidney involvement, although edema, a swelling of the legs, may occur if there is a leak of protein into the urine.

Sometimes people with lupus experience depression or inability to concentrate. Rapid changes in mood or abnormal behavior may occur. These changes may be due to the disease itself, or they may be a reaction to the changes in appearance and energy caused by the disease. In a very small percentage of people, more severe nerve and mental problems, especially convulsions like those in epilepsy, may develop, but they rarely persist.

The doctor will watch you closely for any signs of these problems, and treatment will be started quickly if they occur. Remember that lupus can take many forms. You may have only a few of these problems. Many people with lupus do very well without having major problems.

What conditions have similar sympoms or might be confused with lupus erythematosus?

Some medications taken for other conditions like high blood pressure, certain heart problems, seizures and psychiatric problems such as severe depression, may cause many of the symptoms and abnormal blood tests of lupus. These symptoms almost always go away when these medications are stopped.

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