Publications: Musculoskeletal Systems Biology Lab



1. Jacobs CR, Huang H, Kwon RY. Intro­duc­tion to Cell Mechan­ics and Mechanobi­ol­ogy. Gar­land Sci­ence, 2012.

Book Chap­ters

1. Kwon RY, Hoey D, Jacobs CR. Mechanobi­ol­ogy of pri­mary cilia. In Cel­lu­lar and Bio­mol­e­c­u­lar Mechan­ics and Mechanobi­ol­ogy, A Gefen Ed., Springer, 2011, 99–124.



19. Srinivasan S, Ausk BJ, Bain SD, Gardiner EM, KwonRY, Gross TS. Rest intervals reduce the number of loading bouts required to enhance bone formation. Med Sci Sports Exerc, 2014, In Press.
18. Reci­doro AM, Roof AC, Schmitt M, Wor­ton LE, Petrie T, Strand N, Ausk BJ, Moon RT, Srini­vasan S, Gar­diner EM, Kamin­sky W, Bain SD, Allan CH, Gross TS, Kwon RY. Bot­u­linum toxin induces mus­cle paral­y­sis and inhibits bone regen­er­a­tion in zebrafish. J Bone Miner Res, In Press.
17. Worton LE, Kwon RY, Gardiner EM, Gross TS, Srinivasan S. Enhancement of flow-induced AP-1 gene expression by Cyclosporin A requires NFAT-independent signaling in bone cells. Cell Mol Bioeng, In Press.
16. Srinivasan S, Threet D, Worton LE, Ausk BJ, Bain SD, Gardiner EM, Kwon RY, Gross TS. Distinct Cyclosporin A doses are required to enhance bone formation induced by cyclic and rest-inserted loading in the senescent skeleton. PLoS ONE, 2014, 9(1): e84868.

15. Wor­ton LE, Ausk BJ, Downey LM, Bain SD, Gar­diner EM, Srini­vasan S, Gross TS, Kwon RY. Systems-based iden­ti­fi­ca­tion of tem­po­ral pro­cess­ing path­ways dur­ing bone cell mechan­otrans­duc­tion. PLoS ONE, 2013, 8(9): e74205.
14. Ausk BJ, Huber P, Srini­vasan S, Bain SD, Kwon RY, McNa­mara E, Poli­achik SL, Sybrowsky CL, Gross TS. Meta­phy­seal and dia­phy­seal bone loss in the tibia fol­low­ing tran­sient mus­cle paral­y­sis are spa­tiotem­po­rally dis­tinct resorp­tion events. Bone, 2013, 57(2): 413–422.

13. Sanyal A, Gupta A, Bayrak­tar HH, Kwon RY, Keav­eny TM. Shear strength behav­ior of human tra­bec­u­lar bone. J Bio­mech, 2012, 45(15):2513–2519.
12. Kwon RY, Meays DR, Jones J, Meilan AS, Mira­montes R, Kar­dos N, Yeh JC, Fran­gos JA. Skele­tal adap­ta­tion to intramedullary pressure-induced inter­sti­tial fluid flow in bone is enhanced in mice sub­jected to tar­geted osteo­cyte abla­tion. PLoS ONE, 2012, 7(3) e33336.

11. Kwon RY, Fran­gos JA. Quan­tifi­ca­tion of lacunar-canalicular fluid flow through com­pu­ta­tional mod­el­ing of flu­o­res­cence recov­ery after pho­to­bleach­ing. Cell Mol Bio­eng, 2010, 3(3) 296–306.
10. Kwon RY, Temiyasathit S, Tum­mala P, Quah CC, Jacobs CR. Primary-cilium depen­dent mechanosens­ing is medi­ated by adeny­lyl cyclase 6 and cyclic AMP in bone cells. FASEB J, 2010, 24(8) 2859–2868.
9. Kwon RY, Meays DR, Tang WJ, Fran­gos JA. Microflu­idic enhance­ment of intramedullary pres­sure increases inter­sti­tial fluid flow and inhibits bone loss in hindlimb sus­pended mice. J Bone Miner Res, 2010, 25(8) 1798–1807.

8. Arns­dorf EJ, Tum­mala P, Kwon RY, Jacobs CR. Mechan­i­cally induced osteogenic dif­fer­en­ti­a­tion — the role of RhoA, ROCKII and cytoskele­tal dynam­ics. J Cell Sci, 2009, 122(4) 546–53.
7. Doll JC, Har­jee N, Kle­jwa N, Kwon RY, Coulthard SM, Pet­zold BC, Good­man MB, Pruitt BL. SU-8 force sens­ing pil­lar arrays for bio­log­i­cal mea­sure­ments. Lab on a Chip, 2009, 9 1449–1454.

6. Kwon RY, Lew AJ, Jacobs CR. A microstruc­turally informed model for the mechan­i­cal response of three-dimensional actin net­works. Com­put Meth­ods Bio­mech Bio­med Engin, 2008, 11(4) 407–18.
5. You L, Temiyasathit S, Lee P, Kim CH, Tum­mala P, Yao W, Kingery W, Mal­one AM, Kwon RY, Jacobs CR. Osteo­cytes as mechanosen­sors in the inhi­bi­tion of bone resorp­tion due to mechan­i­cal load­ing. Bone, 2008 42(1) 172–9.

4. Mal­one AM, Ander­son CT, Tum­mala P, Kwon RY, John­ston TR, Stearns T, Jacobs CR. Pri­mary cilia medi­ate mechanosens­ing in bone cells by a calcium-independent mech­a­nism. Proc Natl Acad Sci USA, 2007, 104(33) 13325–30.
3. Kwon RY, Jacobs CR. Time-dependent defor­ma­tions in bone cells exposed to fluid flow in vitro: inves­ti­gat­ing the role of cel­lu­lar defor­ma­tion in fluid flow-induced sig­nal­ing. J Bio­mech, 2007, 40 (14) 3162–8.
2. Mal­one AM, Batra NN, Shiv­aram G, Kwon RY, You L, Kim CH, Rodriguez J, Jair K, Jacobs CR. The role of actin cytoskele­ton in oscil­la­tory fluid flow-induced sig­nal­ing in MC3T3-E1 osteoblasts. Am J Phys­iol Cell Phys­iol, 2007, 292(5) C1830-6.

1. Bayrak­tar HH, Gupta A, Kwon RY, Papadopou­los P, Keav­eny TM. The mod­i­fied super-ellipsoid yield cri­te­rion for human tra­bec­u­lar bone. J Bio­mech Eng, 2004, 126(6) 677–84.