Post-Doc Univ. of Cincinnati - Bone Physiology (1999)
Ph.D. Clemson University - Bioengineering (1996)
M.S. Clemson University - Engineering Mechanics (1992)
B.S. Birla Institute of Tech. and Science, India - Mechanical Engineering (1989)
My research interests are in the broad areas of hard tissue and cellular physiology, mechanotransduction, and in developing exercise based and tissue-engineered solutions to bone loss pathologies. In our research, we utilize a number of technologies from animal and cell culture models, imaging, histomorphometry, immunohistochemistry and gene expression profiling along with complex, multi-scale computational models. My current focus area involves the exploration of bone mechanotransduction using agent based modeling techniques developed for the analysis of general classes of complex adaptive systems. These studies have long term potential towards providing unique insights into how networked cells within the bone syncytium perceive and respond to mechanical stimuli and are expected to lead to the development of computational frameworks for the design of potent exercise strategies to augment bone mass and strength in humans.
Current Academic Appointments
Adjunct Research Associate Professor
Research Associate Professor
Journal of Biomechanics Award, American Society of Biomechanics (2001)
Srinivasan, S., Gross, T.S., and Bain, S.D. (Epub 2012). Bone Mechanotransduction May Require Augmentation in Order to Strengthen The Senescent Skeleton. Ageing Research Reviews.
Ausk, B.J., Huber, P., Poliachik, S.L., Bain, S.D., Srinivasan, S., Gross, T.S. (2012). Cortical bone resorption following muscle paralysis is spatially heterogeneous. Bone, 50:14-22.
Srinivasan, S., Ausk B.J., Prasad J., Threet D., Bain S.D., Richardson T.S., Gross T.S. (2010). Rescueing Loading Induced Bone Formation at Senescence. PLoS Comput Biol, 6(9): e1000924.
Poliachik, S.L., Threet, D., Srinivasan, S., Gross, T.S. (2008). 32 wk old C3H/H3J mice actively respond to mechanical loading. Bone, 42(4):653-659.
S. Srinivasan, B.J. Ausk, S.L. Poliachik, S.E. Warner, T.S. Gross, “Rest-Inserted Loading Rapidly Amplifies the Response of Bone to Small Increases in Strain and Load Cycle,” Journal of Applied Physiology, 102, 1945-1952, 2007.
B.J. Ausk, T.S. Gross, S. Srinivasan, “An Agent Based Model for Real-Time Signaling Induced in Osteocytic Networks by Mechanical Stimuli,” Journal of Biomechanics, 39, 2638-2646, 2006.
K. Hankenson, P. Bornstein, S.D. Bain, T.S. Gross, S. Srinivasan, “Mice lacking thrombospondin-2 show an atypical pattern of endocortical and periosteal bone formation in response to mechanical loading”, Bone, 38, 310-316, 2006.
T.S. Gross, K.A. King, N.A. Rabaia, P. Pathare, S. Srinivasan, “Upregulation of Osteopontin by Osteocytes Deprived of Mechanical Loading or Oxygen,” Journal of Bone Mineral Research, 20, 250-256, 2005.
T.S. Gross, S.L. Poliachik, B.J. Ausk, D.A. Sanford, B. A. Becker, S. Srinivasan, “Why Rest Stimulates Bone Formation: A Hypothesis Based upon Complex Adaptive Phenomenon”, Exercise and Sports Sciences Reviews, 32, 9-13, 2004.