Edith M. Gardiner, Ph.D.

Edith Gardiner Edith Landscape


Post-Doc Garvan Institute of Medical Research, Australia -- Bone biology (1993)

Post-Doc Yale University Biology Department -- Oncogenes (1989)

Ph.D. Yale University School of Medicine -- Human Genetics (1988)

B.S. Duke University -- Biology (1977)


P: 206.897.5608
F: 206.897.5611 


Edith Gardiner


Research Interests

• Neural control of osteoblast lineage cells 
• Neuropeptide Y involvement in phosphate and calcium homeostatic modulation of bone
• Wnt pathway in bone regulation and in cancer metastasis to the skeleton 


Current Academic Appointments

Acting Associate Professor
Department of Orthopaedics and Sports Medicine, The University of Washington (2010-present)




Editorial Board, Endocrinology -- 2009-12    
Editorial Board, Journal of Bone and Mineral Research -- 2004-09    
Hull Award, Yale Comprehensive Cancer Center, Yale University -- 1991, 1992


Recent Publications

Srinivasan, S., Ausk, B.J., Bain, S.D., Gardiner, E.M., Kwon, R.Y., Gross, T.S.  2014.  "Rest-intervals reduce the number of loading bouts required to enhance bone formation"  Med Sci Sports Exercise in press  (accepted August 12, 2014).

Recidoro, A., Roof, A., Schmitt, M., Worton, L., Strand, N., Ausk, B., Srinivasan, S., Gardiner, E., Moon, R., Kaminsky, W., Bain, S., Allen, C., Gross, T., Kwon, R.  2014 "Botulinum toxin induces muscle paralysis and inhibits bone regeneration in zebrafish"  J Bone Miner Res (May 7). [Epub ahead of print] 

Vela, I., Morrissey, C., Zhang, X., Chen, S., Corey, S., Strutton, G.M., Nelson, C.C., Nicol, D.L., Clements, J.A., Gardiner, E.M.  2014.  "PITX2 and non-canonical Wnt pathway interaction in metastatic prostate cancer"  Clin Exp Metastasis 31: 199-211. 

Srinivasan, S., Threet, D., Worton, L.E., Ausk, B.J., Bain, S.D., Gardiner, E.M., Kwon, R.Y., Gross, T.S.  2014.  "Distinct cyclosporin A doses are required to enhance bone formation induced by cyclic and rest-inserted loading in the senescent skeleton"  PLoS One Jan 3;9(1):e84868.  

Worton, L.E., Ausk, B.J., Downey, L.M., Bain, S.D., Gardiner, E.M., Srinivasan, S., Gross, T.S., Kwon, R.Y.  2013.  "Systems based identification of temporal processing pathways during bone cell mechanotransduction"  PLOS One Sep 11;8(9):e74205.   

Allison S.J., Baldock P.A., Enriquez R.F., Lin E.J., During M.J., Gardiner E.M., Eisman J.A., Sainsbury A., Herzog H. 2009.  "Critical interplay between neuropeptide Y and sex steroid pathways in bone and adipose tissue homeostasis." J Bone Miner Res. 24: 294-304.

Baldock P.A., Allison S.J., Lundberg P., Lee N.J., Slack K., Lin E.J., Enriquez R.F., McDonald M.M., Zhang L., During M.J., Little D.G., Eisman J.A., Gardiner E.M., Yulyaningsih E., Lin S., Sainsbury A., Herzog H.  2007.  "Novel role of Y1 receptors in the coordinated regulation of bone and energy homeostasis."  J Biol Chem. 282: 19092-102.

Lundberg P., Allison S..J, Lee N., Baldock P.A., Brouard N., Rost S., Enriquez R., Sainsbury A., Lamghari M., Simmons P., Eisman J.A., Gardiner E.M., Herzog H.  2007.  "Greater bone formation of Y2 knockout mice is associated with increased osteoprogenitor numbers and altered Y1-receptor expression." J Biol Chem. 282: 19082-91.

Shi Y-C, Worton L., Esteban L., Baldock P., Fong C., Eisman J.A., Gardiner E.M. 2007 "Effects of continuous activation of vitamin D and Wnt response pathways on osteoblastic proliferation and differentiation."  Bone 41:  87-96.

Allison S.J., Baldock P., Sainsbury A., Enriquez R.F., Lee N.J., Lin E.J., Klugman M., During M., Eisman J.A., Li M., Pan L.C., Herzog H., Gardiner E.M.  2006.  "Conditional deletion of hypothalamic Y2 receptors reverts gonadectomy-induced bone loss in adult mice." J Biol Chem. 281: 23436-44.

Baldock P.A., Thomas G.P., Hodge J., Baker S.U.K., Dressel U., O’Loughlin P., Nicholson G., Briffa K.H., Eisman J.A., Gardiner E.M. 2006.  "Vitamin D action and regulation of bone remodelling:  Control of osteoclastogenesis by the mature osteoblast." J Bone Miner Res. 21: 1618-26.

Baldock P.A., Sainsbury A., Allison S.J., Lin E-J.D, Couzens M., Boey D., Enriquez R.F., During M., Herzog H., Gardiner E.M. 2005 "Hypothalamic control of bone formation: Distinct actions of leptin and Y2 receptor pathways."  J Bone Miner Res. 20:1851-57.

Smith E.J., McEvoy A., Little D.G., Baldock P.A., Eisman J.A., Gardiner, E.M.  2004. "Transient retention of endochondral cartilaginous matrix with bisphosphonate treatment in a long-term rabbit model of distraction osteogenesis." J Bone Miner Res. 19:1698-705.

Sainsbury A., Baldock P.A., Schwarzer, C., Ueno N., Enriquez R.F., Couzens M., Inui A., Herzog H. Gardiner E.M.  2003.  "Synergistic reduction in adiposity and increase in bone mass in Y2 / Y4 receptor double knockout mice."  Molec Cell Biol. 23: 5225-5233.

Baldock .P.A., Sainsbury, A., Couzens, M., Enriquez, R.F., Thomas, G.P., Gardiner, E.M., Herzog, H.  2002. "Hypothalamic Y2 receptors regulate bone formation."  J Clin Invest. 14: 1908-16.