Ulbrecht JS, Hurley T, Mauger DT, Cavanagh PR.
In a recent publication of Diabetes Care, Department of Orthopaedics and Sports Medicine Faculty member Peter Cavanagh assessed the efficacy of in-shoe orthoses that were designed based on shape and barefoot plantar pressure in reducing the incidence of submetatarsal head plantar ulcers in people with diabetes, peripheral neuropathy, and a history of similar prior ulceration.
In a single-blinded multicenter randomized controlled trial, subjects were randomized to wear shape- and pressure-based orthoses (experimental, n = 66) or standard-of-care A5513 orthoses (control, n = 64). Patients were followed for 15 months, until a study end point (forefoot plantar ulcer or nonulcerative plantar forefoot lesion) or to study termination. Proportional hazards regression was used for analysis.
There was a trend in the composite primary end point (both ulcers and nonulcerative lesions) across the full follow-up period (P = 0.13) in favor of the...Read more...